BCL7A is silenced by hypermethylation to promote acute myeloid leukemia.

Juan Rodrigo Patiño-MercauCarlos Baliñas-GaviraAlvaro AndradesMaria S Benitez-CantosAna Ercegovič RotMaría Isabel Rodríguez Juan Carlos Álvarez-Perez Marta Cuadros Pedro P Medina

Published in: Biomarker research (2023)

BCL7A expression is silenced in AML by promoter methylation. In addition, restoration of BCL7A expression exerts tumor suppressor activity in AML cell lines and xenograft models.

Keyphrases

acute myeloid leukemia
poor prognosis
allogeneic hematopoietic stem cell transplantation
dna methylation
gene expression
binding protein
long non coding rna
genome wide