Factors Associated With Severity of COVID-19 Disease in a Multicenter Cohort of People With HIV in the United States, March-December 2020.
Adrienne E ShapiroRachel A Bender IgnacioBridget M WhitneyJoseph A DelaneyRobin M NanceLaura BamfordDarcy WootenJeanne C KerulyGreer BurkholderSonia NapravnikKenneth H MayerAllison R WebelH Nina KimStephen E Van RompaeyKaterina ChristopoulosJeffrey JacobsonMaile KarrisDavey SmithMallory O JohnsonAmanda WilligJoseph J EronPeter HuntRichard D MooreMichael S SaagW Christopher MathewsHeidi M CraneEdward R CachayMari M Kitahatanull nullPublished in: Journal of acquired immune deficiency syndromes (1999) (2022)
PWH with CD4 count <350 cells/mm 3 , and a history of CD4 count <200 cells/mm 3 , have a clear excess risk of severe COVID-19, accounting for comorbidities associated with severe outcomes. PWH with these risk factors should be prioritized for COVID-19 vaccination and early treatment and monitored closely for worsening illness.
Keyphrases
- coronavirus disease
- sars cov
- induced apoptosis
- risk factors
- cell cycle arrest
- early onset
- human immunodeficiency virus
- endoplasmic reticulum stress
- hiv infected
- type diabetes
- hiv positive
- respiratory syndrome coronavirus
- hiv aids
- hiv testing
- clinical trial
- metabolic syndrome
- cell death
- adipose tissue
- cross sectional
- men who have sex with men
- drug induced
- pi k akt
- replacement therapy