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Combined high-dose intra-arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma.

Anabel RodriguezSantiago ZugbiFlavio RequejoAlejandra DeuClaudia SamporMariana SgroiAndrea BosalehAdriana FandiñoPaula S SchaiquevichGuillermo L Chantada
Published in: Pediatric blood & cancer (2018)
Patients with retinoblastoma and central nervous system (CNS) involvement are rarely curable with available treatments. We designed a high-dose intra-arterial regimen targeting the ophthalmic artery and chiasm combined with intrathecal chemotherapy to treat a 4-year-old patient with retinoblastoma metastasized to the CNS. After three cycles of this regimen, including carboplatin, melphalan, and intrathecal topotecan, a partial response of the orbital tumor mass and chiasmatic lesion, and complete response in the cerebrospinal fluid and bone marrow were achieved. This new treatment strategy may be explored as a treatment component for patients with overt extraocular retinoblastoma and CNS dissemination.
Keyphrases
  • high dose
  • bone marrow
  • cerebrospinal fluid
  • blood brain barrier
  • randomized controlled trial
  • stem cell transplantation
  • squamous cell carcinoma
  • radiation therapy