Evaluating different low-density lipoprotein cholesterol thresholds to initiate statin for prevention of cardiovascular diseases in patients with type 2 diabetes mellitus: A target trial emulation study.
Eric Yuk Fai WanWanchun XuAnna Hoi Ying MokWeng Yee ChinEsther Yee Tak YuCeline Sze Ling ChuiEsther Wai Yin ChanIan Chi Kei WongCindy Lo Kuen LamGoodarz DanaeiPublished in: Diabetes, obesity & metabolism (2024)
Compared with the threshold of 2.6 mmol/L, initiating statin in patients with a lower baseline LDL-C level at 1.8-2.5 mmol/L can further reduce the risks of CVD and all-cause mortality without significantly increasing the risk of major adverse events in patients with T2DM, including patients aged >75 years.
Keyphrases
- cardiovascular disease
- end stage renal disease
- coronary artery disease
- ejection fraction
- newly diagnosed
- clinical trial
- prognostic factors
- randomized controlled trial
- low density lipoprotein
- peritoneal dialysis
- study protocol
- adipose tissue
- cardiovascular events
- metabolic syndrome
- skeletal muscle
- insulin resistance
- climate change
- weight loss
- patient reported