Effects of Mini-Dystrophin on Dystrophin-Deficient, Human Skeletal Muscle-Derived Cells.
Jinhong MengJohn R CounsellJennifer E MorganPublished in: International journal of molecular sciences (2020)
Ectopic expression of dystrophin in cultured human skeletal muscle-derived cells may affect their proliferation and differentiation capacity. Caution should be taken when considering genetic correction of autologous stem cells to express dystrophin driven by a constitutive promoter.
Keyphrases
- skeletal muscle
- duchenne muscular dystrophy
- endothelial cells
- induced apoptosis
- stem cells
- muscular dystrophy
- cell cycle arrest
- insulin resistance
- induced pluripotent stem cells
- signaling pathway
- dna methylation
- gene expression
- endoplasmic reticulum stress
- pluripotent stem cells
- type diabetes
- cell death
- cell proliferation
- metabolic syndrome