Emotional blunting in depression in the PREDDICT clinical trial: inflammation-stratified augmentation of vortioxetine with celecoxib.

This analysis suggests favourable effects of vortioxetine on emotional blunting both in short and long-term course. The beneficial impact of vortioxetine on emotional blunting was weaker in celecoxib-augmented patients compared to placebo, possibly due to pharmacokinetic interactions.