Spontaneous breathing trial with pressure support on positive end-expiratory pressure and extensive use of non-invasive ventilation versus T-piece in difficult-to-wean patients from mechanical ventilation: a randomized controlled trial.
Mehdi MezidiHodane YonisLouis ChauvelotGuillaume DenielFrançois DhelftMaxime GailletInes NoirotLaure FollietPaul ChabertGuillaume DavidWilliam DanjouLoredana BaboiClotilde BettingerPauline BernonMehdi GirardJudith ProvoostAlwin BazzaniLaurent BitkerJean-Christophe RichardPublished in: Annals of intensive care (2024)
An extensively-assisted weaning strategy did not lead to a shorter time to successful extubation than a standard weaning strategy. Trial registration The trial was registered on ClinicalTrials.gov (NCT03861117), on March 1, 2019, before the inclusion of the first patient. https://clinicaltrials.gov/study/NCT03861117 .
Keyphrases
- mechanical ventilation
- acute respiratory distress syndrome
- intensive care unit
- respiratory failure
- study protocol
- phase iii
- phase ii
- end stage renal disease
- clinical trial
- extracorporeal membrane oxygenation
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- randomized controlled trial
- multidrug resistant
- prognostic factors
- case report
- cardiac surgery