Low expression levels of miRNA-155 and miRNA-499a are associated with obesity in Type 2 diabetes.
Andrea LatiniGiada De BenedittisCinzia CiccacciGiuseppe NovelliVincenza SpallonePaola BorgianiPublished in: Epigenomics (2024)
Background & aims: This study investigated a possible correlation between three circulating miRNAs, previously observed to be associated to diabetic polyneuropathy, and the obesity condition. Methods & results: The expression levels of miR-128a, miR-155 and miR499a were evaluated in 49 participants with Type 2 diabetes, divided into different groups based on the presence or absence of obesity and central obesity. The analyses revealed a significant decrease of miR-155 and miR-499a expression levels in obese subjects. In particular, the reduction appears to be even more significant in Type 2 diabetes subjects with central obesity. Conclusion: The results suggest that these miRNAs could be involved in obesity-driven pathogenetic mechanisms.
Keyphrases
- type diabetes
- insulin resistance
- weight loss
- metabolic syndrome
- long non coding rna
- cell proliferation
- poor prognosis
- high fat diet induced
- weight gain
- long noncoding rna
- glycemic control
- adipose tissue
- cardiovascular disease
- bariatric surgery
- skeletal muscle
- high resolution
- obese patients
- physical activity
- single cell