Mitosis can drive cell cannibalism through entosis.
Joanne DurganYun-Yu TsengJens C HamannMarie-Charlotte DomartLucy CollinsonAlan HallMichael OverholtzerOliver FloreyPublished in: eLife (2017)
Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which depend on RhoA activation and are phenocopied by Rap1 inhibition, permit subsequent entosis. Mitotic entosis occurs constitutively in some human cancer cell lines and mitotic index correlates with cell cannibalism in primary human breast tumours. Adherent, wild-type cells can act efficiently as entotic hosts, suggesting that normal epithelia may engulf and kill aberrantly dividing neighbours. Finally, we report that Paclitaxel/taxol promotes mitotic rounding and subsequent entosis, revealing an unconventional activity of this drug. Together, our data uncover an intriguing link between cell division and cannibalism, of significance to both cancer and chemotherapy.
Keyphrases
- cell cycle
- endothelial cells
- papillary thyroid
- single cell
- induced pluripotent stem cells
- pluripotent stem cells
- cell therapy
- stem cells
- emergency department
- cell proliferation
- signaling pathway
- mesenchymal stem cells
- bone marrow
- cell death
- squamous cell
- escherichia coli
- pseudomonas aeruginosa
- oxidative stress
- big data
- lymph node metastasis
- artificial intelligence
- cystic fibrosis
- drug induced
- cell migration
- pi k akt