AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer.
Mauricio Marquez-PalenciaLuis Reza HerreraPravat Kumar ParidaSuvranil GhoshKangsan KimNikitha M DasPaula I Gonzalez EricssonMelinda E SandersBret C MobleySebastian DiegelerTodd A AguileraYan PengCheryl M LewisCarlos L ArteagaAriella B HankerAngelique W WhitehurstJames B LorensRolf A BrekkenAnthony J DavisSrinivas MalladiPublished in: Cancer research (2024)
Nuclear AXL and WRNIP1 interact and mediate replication stress response, promote therapy resistance, and support metastatic progression, indicating that targeting the AXL/WRNIP1 axis is a potentially viable therapeutic strategy for breast cancer.