Construction of C(sp²)-Si Bonds via Ligand-Promoted C-C Bonds Cleavage of Unstrained Ketones.

Herein, we report an efficient palladium-catalyzed silylation of aryl and alkenyl ketones via C-C bond cleavage and C-Si bond formation. This protocol features high efficiency and broad substrate scope. Further applications in the late-stage diversification of biologically important molecules demonstrate the synthetic utility of this method.