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Emerging Direct Targeting β-Catenin Agents.

Marianna NalliDomiziana MasciAndrea UrbaniGiuseppe La ReginaRomano Silvestri
Published in: Molecules (Basel, Switzerland) (2022)
Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin drugs for clinical treatments have not been approved so far. We focused on direct β-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule β-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of β-catenin agents.
Keyphrases
  • cell proliferation
  • epithelial mesenchymal transition
  • small molecule
  • healthcare
  • stem cells
  • squamous cell carcinoma
  • bone marrow
  • drug delivery