Pathological examination of factors involved in PD-L1 expression in patients with oral tongue squamous cell carcinoma.

Yu KoyamaChiharu OgawaChihiro KuriharaNao HashimotoShota ShinagawaHiroya OkazakiTakumi KoyamaKeisuke SugaharaAkira Katakura

Published in: Maxillofacial plastic and reconstructive surgery (2024)

The expression of PD-L1 demonstrated an association with α-SMA and p53 positivity. In addition, compared with the expression of p53, the expression of α-SMA demonstrated a higher association with PD-L1 expression in patients with a high CPS. The abovementioned findings suggest that the interactions between CAFs, cancer cells, and immunocompetent cells may regulate the expression of PD-L1.

Keyphrases

poor prognosis
squamous cell carcinoma
binding protein
induced apoptosis
long non coding rna
cell proliferation
oxidative stress
radiation therapy
endoplasmic reticulum stress