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Pathological examination of factors involved in PD-L1 expression in patients with oral tongue squamous cell carcinoma.

Yu KoyamaChiharu OgawaChihiro KuriharaNao HashimotoShota ShinagawaHiroya OkazakiTakumi KoyamaKeisuke SugaharaAkira Katakura
Published in: Maxillofacial plastic and reconstructive surgery (2024)
The expression of PD-L1 demonstrated an association with α-SMA and p53 positivity. In addition, compared with the expression of p53, the expression of α-SMA demonstrated a higher association with PD-L1 expression in patients with a high CPS. The abovementioned findings suggest that the interactions between CAFs, cancer cells, and immunocompetent cells may regulate the expression of PD-L1.
Keyphrases
  • poor prognosis
  • squamous cell carcinoma
  • binding protein
  • induced apoptosis
  • long non coding rna
  • cell proliferation
  • oxidative stress
  • radiation therapy
  • endoplasmic reticulum stress