Poly (ADP-Ribose) and α-synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity.

Fabrice LucienEduardo E BenarrochAidan MullanFarwa AliBradley F BoeveMichelle M MielkeRonald C PetersenYohan KimCole StangEmanuele CamerucciOwen A RossZbigniew K WszolekDavid KnopmanJames BowerWolfgang SingerRodolfo Savica

Published in: PloS one (2022)

Non-invasive determination of α-synuclein-positive extracellular vesicles may provide a potential non-invasive marker of PD disease severity, and longitudinal studies are needed to evaluate the role of α-synuclein-positive extracellular vesicles as a marker of disease progression.

Keyphrases

parkinson disease
deep brain stimulation
cross sectional
solid phase extraction
case control
human health
climate change
high resolution
mass spectrometry