Time-efficient measurement of subtle blood-brain barrier leakage using a T1 mapping MRI protocol at 7 T.
Marieke van den KerkhofPaulien H M VoorterLisanne P W CanjelsJoost J A de JongRobert J Van OostenbruggeAbraham A KroonJacobus F A JansenWalter H BackesPublished in: Magnetic resonance in medicine (2020)
The sparsely sampled protocol was demonstrated to be sensitive to quantify subtle BBB leakage, despite using only three T1 maps. Due to the time-efficiency of this method, it will become more feasible to incorporate BBB leakage measurements in clinical research MRI protocols.