Login / Signup

A Dynamic Protocol to Explore NLRP3 Inflammasome Activation in Cerebral Organoids.

Dana El Soufi El SabbaghLiliana AttisanoAna Cristina AndreazzaAlencar Kolinski Machado
Published in: International journal of molecular sciences (2024)
The NLRP3 inflammasome plays a crucial role in the inflammatory response, reacting to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). This response is essential for combating infections and restoring tissue homeostasis. However, chronic activation can lead to detrimental effects, particularly in neuropsychiatric and neurodegenerative diseases. Our study seeks to provide a method to effectively measure the NLRP3 inflammasome's activation within cerebral organoids (COs), providing insights into the underlying pathophysiology of these conditions and enabling future studies to investigate the development of targeted therapies.
Keyphrases
  • nlrp inflammasome
  • inflammatory response
  • subarachnoid hemorrhage
  • randomized controlled trial
  • lipopolysaccharide induced
  • single molecule
  • current status
  • candida albicans