Login / Signup

Molecular characterization and whole-genome sequencing of Corynebacterium diphtheriae causing skin lesion.

Juliana Nunes RamosMax Roberto Batista de AraújoLincoln de Oliveira Sant'AnnaSérgio BokermannCarlos Henrique CamargoFernanda Diniz PratesCláudio Tavares SacchiVerônica Viana VieiraKaroline Rodrigues CamposMarlon Benedito Nascimento SantosMarcus Vinícius Canário VianaVasco Ariston de Carvalho AzevedoFlávia Figueira AburjaileAna Luíza Mattos-GuaraldiLouisy Sanches Dos Santos
Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2023)
We present a case of skin lesion caused by nontoxigenic Corynebacterium diphtheriae. Genomic taxonomy analyses corroborated the preliminary identification provided by mass spectrometry. The strain showed a susceptible phenotype with increased exposure to penicillin, the first drug of choice for the treatment. An empty type 1 class integron carrying only the sul1 gene, which encodes sulfonamide resistance, was found flanked by transposases. Virulence factors involved in adherence and iron uptake, as well as the CRISPR-Cas system, were predicted. MLST analysis revealed the ST-681, previously reported in French Guiana, a European territory.
Keyphrases