Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis.
Alsya J AffandiTiago CarvalheiroAndrea OttriaJasper Ca BroenLara Bossini-CastilloRalph G TielandLenny van BonEleni ChouriMarzia RossatoJorre S MertensSamuel García PérezAridaman PanditLaurie Mg de KroonRomy B ChristmannJavier MartinJoel Ag van RoonTimothy Rdj RadstakeWioleta MarutPublished in: Annals of the rheumatic diseases (2019)
We show at least two pathways potentially causing low RUNX3 level in SSc pDCs, and we demonstrate the detrimental effect of loss of Runx3 in SSc model further underscoring the role of pDCs in this disease.