PUS7-dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression.

Yongxia ChangHao JinYun CuiFeng YangKanghua ChenWenjun KuangChunxiao HuoZhangqi XuYa LiAifu LinBo YangWei LiuShanshan XieTianhua Zhou

Published in: Clinical and translational medicine (2024)

PUS7 enhances the translation efficiency of ALKBH3 through its pseudouridylation activity on ALKBH3 mRNA, thereby inhibiting gastric tumourigenesis. The expression levels of PUS7 and ALKBH3 are significantly correlated in gastric tumours, which may be potential prognostic predictors and therapeutic targets for patients with gastric cancer.

Keyphrases

binding protein
poor prognosis
signaling pathway
human health