Immune Activation Induces Telomeric DNA Damage and Promotes Short-Lived Effector T Cell Differentiation in Chronic HCV Infection.

Lam Nhat NguyenLam Ngoc Thao NguyenJuan ZhaoMadison SchankXindi DangDechao CaoSushant KhanalBal Krishna Chand ThakuriJinyu ZhangZeyuan LuXiao Y WuMohamed El GazzarShunbin NingLing WangJonathan P MoormanZhi Q Yao

Published in: Hepatology (Baltimore, Md.) (2021)

These results suggest that modulation of immune activation through inhibiting Akt signaling and protecting telomeres through enhancing TRF2 expression may open therapeutic strategies to fine tune the adaptive immune responses in the setting of persistent immune activation and inflammation during chronic HCV infection.

Keyphrases

dna damage
hepatitis c virus
immune response
oxidative stress
signaling pathway
poor prognosis
cell proliferation
air pollution
minimally invasive
dna repair
regulatory t cells
binding protein