Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients.

Anudeep Yekula Tiffaney HsiaRobert R KitchenSudipto K ChakraborttyWei YuSyeda M BatoolBrian LewisAntoni J SzeglowskiRalph WeisslederHakho LeeAndrew S ChiTracy BatchelorBob S CarterXandra O BreakefieldJohan Skog Leonora Balaj

Published in: Neuro-oncology advances (2023)

This study demonstrates that genetic composition analysis of serum EVs may aid in therapeutic stratification to identify patients with dacomitinib-responsive GBM.

Keyphrases

end stage renal disease
small cell lung cancer
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
epidermal growth factor receptor
genome wide
cross sectional
cancer therapy
copy number
dna methylation