Robotic right ventricle is a biohybrid platform that simulates right ventricular function in (patho)physiological conditions and intervention.
Manisha SinghJean BonnemainCaglar OzturkBrian AyersMossab Y SaeedDiego Quevedo-MorenoMeagan RowlettClara ParkYiling FanChristopher T NguyenEllen T RochePublished in: Nature cardiovascular research (2023)
The increasing recognition of the right ventricle (RV) necessitates the development of RV-focused interventions, devices and testbeds. In this study, we developed a soft robotic model of the right heart that accurately mimics RV biomechanics and hemodynamics, including free wall, septal and valve motion. This model uses a biohybrid approach, combining a chemically treated endocardial scaffold with a soft robotic synthetic myocardium. When connected to a circulatory flow loop, the robotic right ventricle (RRV) replicates real-time hemodynamic changes in healthy and pathological conditions, including volume overload, RV systolic failure and pressure overload. The RRV also mimics clinical markers of RV dysfunction and is validated using an in vivo porcine model. Additionally, the RRV recreates chordae tension, simulating papillary muscle motion, and shows the potential for tricuspid valve repair and replacement in vitro. This work aims to provide a platform for developing tools for research and treatment for RV pathophysiology.
Keyphrases
- mycobacterium tuberculosis
- mitral valve
- minimally invasive
- aortic valve
- left ventricular
- pulmonary artery
- pulmonary hypertension
- robot assisted
- heart failure
- randomized controlled trial
- blood pressure
- aortic stenosis
- high throughput
- skeletal muscle
- transcatheter aortic valve replacement
- high speed
- risk assessment
- high resolution
- human health
- coronary artery
- coronary artery disease
- extracorporeal membrane oxygenation
- cardiac resynchronization therapy
- newly diagnosed
- combination therapy