Stem Cells as a Model of Study of SARS-CoV-2 and COVID-19: A Systematic Review of the Literature.
María Verónica Cuevas-GonzálezAlvaro García PérezAlvaro Edgar González-Aragón PinedaLeón Francisco Espinosa-CristobalAlejandro Donohue-CornejoKarla Lizette Tovar-CarrilloRosa Alicia Saucedo-AcuñaJuan Carlos Cuevas GonzálezPublished in: BioMed research international (2021)
The use of stem cells is a highly relevant therapeutic option. It has been shown in both in vitro studies and clinical trials that it counteracts the excessive secretion of cytokines. There are even more studies that focus on long-term follow-up; thus, the potential for major side effects can be analyzed more clearly. Finally, the ethical use of stem cells from fetal or infant origin needs to be regulated. The study was registered in PROSPERO (no. CRD42021229038). The limitations of the study were because of the methodology employed, the sample was not very large, and the follow-up period of the clinical studies was relatively short.