Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study.
Gemma MoncunillJason CarnesWilliam Chad YoungLindsay N CarppStephen De RosaJoseph J CampoAugusto NhabombaMaxmillian MpinaChenjerai JairoceGreg FinakPaige HaasCarl MurielPhu VanHéctor SanzSheetij DuttaBenjamin MordmüllerSelidji T AgnandjiNúria Díez-PadrisaNana Aba WilliamsJohn J AponteClarissa ValimDaniel E NeafseyClaudia DaubenbergerM Juliana McElrathCarlota DobanoKenneth D StuartRaphaël GottardoPublished in: eLife (2022)
Funding was obtained from the NIH-NIAID (R01AI095789), NIH-NIAID (U19AI128914), PATH Malaria Vaccine Initiative (MVI), and Ministerio de Economía y Competitividad (Instituto de Salud Carlos III, PI11/00423 and PI14/01422). The RNA-seq project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under grant number U19AI110818 to the Broad Institute. This study was also supported by the Vaccine Statistical Support (Bill and Melinda Gates Foundation award INV-008576/OPP1154739 to R.G.). C.D. was the recipient of a Ramon y Cajal Contract from the Ministerio de Economía y Competitividad (RYC-2008-02631). G.M. was the recipient of a Sara Borrell-ISCIII fellowship (CD010/00156) and work was performed with the support of Department of Health, Catalan Government grant (SLT006/17/00109). This research is part of the ISGlobal's Program on the Molecular Mechanisms of Malaria which is partially supported by the Fundación Ramón Areces and we acknowledge support from the Spanish Ministry of Science and Innovation through the 'Centro de Excelencia Severo Ochoa 2019-2023' Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
Keyphrases
- quality improvement
- public health
- healthcare
- rna seq
- infectious diseases
- mental health
- artificial intelligence
- plasmodium falciparum
- single cell
- health information
- endothelial cells
- primary care
- gene expression
- machine learning
- transcription factor
- human health
- social media
- climate change
- health insurance
- induced pluripotent stem cells