Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis.
Fernanda Morales BersteinCarine BiessyVivian ViallonAna Goncalves-SoaresCorinne CasagrandeBertrand HémonNathalie KliemannManon CairatJessica Blanco LopezAline Al NahasKiara ChangEszter VamosFernanda RauberRenata Bertazzi LevyDiana Barbosa CunhaPaula JakszynPietro FerrariPaolo VineisGiovanna MasalaAlberto CatalanoEmily SonestedtYan BornéVerena KatzkeRashmita BajracharyaClaudia AgnoliMarcela GuevaraAlicia HeathLoredana RadoïFrancesca ManciniElisabete WeiderpassJosé María HuertaMaría-José SánchezAnne TjønnelandCecilie KyrøMatthias B SchulzeGuri SkeieMarko LukicTonje BraatenMarc GunterChristopher MillettAntonio AgudoPaul BrennanM Carolina BorgesRebecca C RichmondTom G RichardsonGeorge Davey SmithCaroline L ReltonInge Huybrechtsnull nullPublished in: European journal of nutrition (2023)
We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).