Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases.

Alexander DesukiFrank StaibInes GockelMarkus MoehlerHauke LangStefan BiesterfeldAnnett MadererPeter Robert GalleMartin R BergerCarl Christoph Schimanski

Published in: Canadian journal of gastroenterology & hepatology (2019)

LLGL1 is coexpressed with E-cadherin. Loss of expression of either protein is associated with diffuse gastric cancer and peritoneal metastases. LLGL1 does not impact on proliferation or epithelial-mesenchymal transition (EMT) rather increasing cellular adhesion.

Keyphrases

epithelial mesenchymal transition
poor prognosis
signaling pathway
binding protein
low grade
transforming growth factor
lymph node
long non coding rna
amino acid
high grade
pseudomonas aeruginosa