CircFAM13B promotes the proliferation of hepatocellular carcinoma by sponging miR-212, upregulating E2F5 expression and activating the P53 pathway.

Ying XieXiaofeng HangWensheng XuJing GuYuanjing ZhangJianrong WangXiucui ZhangXinghao CaoJunjie ZhanJunxue WangJianhe Gan

Published in: Cancer cell international (2021)

Our findings revealed the mechanism underlying the regulatory role played by circFAM13B, miR-212 and E2F5 in HCC. This study provides a new theoretical basis and novel target for the clinical prevention and treatment of HCC.

Keyphrases

long non coding rna
cell proliferation
poor prognosis
signaling pathway
long noncoding rna
replacement therapy