Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

Yanglin WuFan HeChenhui ZhangQin ZhangXinlin SuXu ZhuAng LiuWeidong ShiWeifeng LinZhongqin JinHuilin YangJun Lin

Published in: Journal of nanobiotechnology (2021)

Taken together, our results suggested that the benefits of melatonin mainly depend on the ability of modulating gut microbiota and regulating butyrate production.

Keyphrases

signaling pathway
high glucose
pi k akt
diabetic rats
epithelial mesenchymal transition
induced apoptosis
fatty acid
mouse model
endothelial cells
cell proliferation