Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats.

Renan Dal-Fabbro Leopoldo Cosme-Silva Letícia Cabrera Capalbo Antônio Hernandes Chaves-Neto Edilson Ervolino Luciano Tavares Angelo Cintra João Eduardo Gomes-Filho

Published in: International endodontic journal (2021)

Excessive caffeine exposure via gavage in rats was able to exacerbate the volume of periapical bone destruction, and the inflammatory pattern deriving from periapical periodontitis altering the expression of RANKL, IL-1β and TRAP.

Keyphrases

bone loss
weight gain
cone beam computed tomography
bone mineral density
poor prognosis
soft tissue
cone beam
bone regeneration
body composition
postmenopausal women
immune response
binding protein
nuclear factor
weight loss
inflammatory response