Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study.
Shuqing SiAnbreen BiZhaoying YuCheryl SeeSinead KellySonia AmbrogiCelso ArangoInmaculada BaezaNerisa BanajMichael BerkJosefina Castro-FornielesBenedicto Crespo-FacorroJacob J CrouseCovadonga Martinez Diaz-CanejaAnne-Kathrin J FettAdriana ForteaSophia FrangouBenjamin I GoldsteinIan B HickieJoost JanssenKody G KennedyLydia KrabbendamMarinos KyriakopoulosBradley J MacIntoshPedro Silva MoreiraStener NerlandSaül Pascual-DiazMaria Picó-PérezGianfranco SpallettaBjørn Rishovd RundElena de la SernaGianfranco SpallettaGisela SugranyesChao SuoDiana Tordesillas-GutiérrezDaniela VecchioJoaquim RaduaPhilip K McGuireSophia I ThomopoulosNeda JahanshadPaul M ThompsonClaudia BarthIngrid AgartzAnthony JamesMatthew J KemptonPublished in: Molecular psychiatry (2024)
EOP is associated with widespread reductions in cortical GM volume, while WM is affected to a smaller extent. GM volume alterations are associated with age of onset and CPZ equivalent dose but these effects are small compared to case-control differences. Mapping anatomical abnormalities in EOP may lead to a better understanding of the role of psychosis in brain development during childhood and adolescence.