Emerging Therapeutic Targets for Acute Coronary Syndromes: Novel Advancements and Future Directions.
Andreas MitsisMichael MyrianthefsStefanos SokratousGeorgia KarmiotiMichaela KyriakouMichail DrakomathioulakisStergios TzikasNikolaos P E KadoglouEfstratios KaragiannidisAthina NasoufidouNikolaos FragakisAntonios ZiakasGeorge KassimisPublished in: Biomedicines (2024)
Acute coronary syndrome (ACS) remains a major cause of morbidity and mortality worldwide, requiring ongoing efforts to identify novel therapeutic targets to improve patient outcomes. This manuscript reviews promising therapeutic targets for ACS identified through preclinical research, including novel antiplatelet agents, anti-inflammatory drugs, and agents targeting plaque stabilization. Preclinical studies have expounded these agents' efficacy and safety profiles in mitigating key pathophysiological processes underlying ACS, such as platelet activation, inflammation, and plaque instability. Furthermore, ongoing clinical trials are evaluating the efficacy and safety of these agents in ACS patients, with potential implications for optimizing ACS management. Challenges associated with translating preclinical findings into clinical practice, including patient heterogeneity and trial design considerations, are also discussed. Overall, the exploration of emerging therapeutic targets offers promising avenues for advancing ACS treatment strategies and improving patient outcomes.
Keyphrases
- acute coronary syndrome
- percutaneous coronary intervention
- antiplatelet therapy
- clinical trial
- clinical practice
- coronary artery disease
- cell therapy
- anti inflammatory drugs
- stem cells
- single cell
- randomized controlled trial
- phase ii
- study protocol
- phase iii
- systematic review
- drug delivery
- case report
- quality improvement
- current status