Extracellular matrix alterations in the skin of patients affected by psoriasis.
Mariana Fatima Muaccad Gama WagnerThérèse Rachell TheodoroCarlos D' Apparecida Santos Machado FilhoLuiza Keiko Matsuka OyafusoMaria Aparecida da Silva PinhalPublished in: BMC molecular and cell biology (2021)
These results show a possible correlation between the characteristic inflammatory process and alterations in the expression of the extracellular matrix in psoriasis. The increased expression of HPSE2, SYND1, MMP9, and TIMP2, even in the absence of psoriatic plaque, indicates that these molecules may be involved with extracellular matrix changes in the initial alterations the psoriatic process and may be candidates for the development of target treatments.