Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects' Periodontal, Glycemic, and Lipid Profiles.
Ingra G NicchioThamiris CirelliRafael NepomucenoMarco A R HidalgoCarlos Rossa JuniorJoni Augusto CirelliSilvana Regina Perez OrricoSilvana P BarrosLeticia Helena TheodoroRaquel Mantuaneli Scarel CaminagaPublished in: Journal of diabetes research (2021)
Polymorphisms in lipid metabolism genes are associated with susceptibility to T2DM-periodontitis comorbidities, demonstrating gene-sex interaction. The APOB-rs1042031 was the most relevant gene marker related to glucose and lipid metabolism profiles, as well as with obesity and periodontitis.
Keyphrases
- genome wide identification
- genome wide
- fatty acid
- type diabetes
- glycemic control
- genome wide analysis
- copy number
- transcription factor
- dna methylation
- metabolic syndrome
- insulin resistance
- weight loss
- blood glucose
- weight gain
- adipose tissue
- gene expression
- cardiovascular disease
- skeletal muscle
- cardiovascular risk factors
- body mass index
- drug induced