Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping.
Germain HonvoLaetitia LengeléAlexia CharlesJean-Yves ReginsterOlivier BruyèrePublished in: Rheumatology and therapy (2020)
Although current evidence shows some potential for the use of CH and UC as an option for management of patients with OA, there is still room for progress in terms of laboratory and clinical research before any definitive conclusion can be made. Harmonization of outcomes in preclinical studies and longer randomized placebo-controlled trials in larger populations with the use of recommended and validated endpoints are warranted before collagen derivatives can be recommended by large scientific societies.
Keyphrases
- placebo controlled
- double blind
- phase iii
- knee osteoarthritis
- phase ii
- wound healing
- clinical trial
- study protocol
- tissue engineering
- high resolution
- rheumatoid arthritis
- structure activity relationship
- open label
- phase ii study
- room temperature
- randomized controlled trial
- cell therapy
- extracellular matrix
- type diabetes
- locally advanced
- radiation therapy
- mesenchymal stem cells
- squamous cell carcinoma
- high density
- adipose tissue
- metabolic syndrome
- stem cells
- ionic liquid