Seroreversion to Chlamydia trachomatis Pgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia.

Christine Tedijanto Solomon Aragie Sarah Gwyn Dionna M Wittberg Taye Zeru TadegeZerihun TadesseAmbahun ChernetIsabel J B ThompsonScott D Nash Thomas M LietmanDiana L MartinJeremy David Keenan Benjamin F Arnold

Published in: The Journal of infectious diseases (2023)

Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a three-year longitudinal cohort in a high transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 (95% CI: 1.6, 3.5) per 100 person-years.

Keyphrases

young adults
electronic health record
dendritic cells
big data
cross sectional
machine learning