Efficacy and tolerability of lithium in treating acute mania in youth with bipolar disorder: protocol for a systematic review.
Anne C DuffyS PattenS GooddayA WeirN HefferA CiprianiPublished in: International journal of bipolar disorders (2017)
Findings from this systematic review are critically needed to inform clinical practice. We should not generalize findings from adult studies, as children and adolescents are undergoing accelerated physiological and brain development. Therefore, efficacy, tolerability, and acceptability of lithium treatment of acute mania in children compared to adults may be very different. This systematic review has been registered in PROSPERO (CRD42017055675).
Keyphrases
- bipolar disorder
- systematic review
- meta analyses
- liver failure
- major depressive disorder
- clinical practice
- young adults
- open label
- respiratory failure
- randomized controlled trial
- mental health
- drug induced
- aortic dissection
- clinical trial
- resting state
- white matter
- solid state
- multiple sclerosis
- placebo controlled
- replacement therapy