Prophylactic A-Blockers for Radiotherapy-Induced Lower Urinary Tract Symptoms in Men with Prostate Cancer: A Phase III Randomized Trial.
Tamim NiaziEdmond KaldanySteven TisseverasingheTalía MalagónBoris BahoricVictor McPhersonAlexis Rompre-BrodeurMaurice AnidjarPublished in: Cancers (2023)
Prophylactic α-blockers were not effective at significantly reducing RI-LUTSs in prostate cancer patients treated with EBRT. Treating patients with α-blockers at the onset of RI-LUTSs will avoid unnecessary drug exposure and toxicity.
Keyphrases
- prostate cancer
- phase iii
- angiotensin converting enzyme
- lower urinary tract symptoms
- radical prostatectomy
- benign prostatic hyperplasia
- open label
- clinical trial
- angiotensin ii
- early stage
- drug induced
- high glucose
- oxidative stress
- phase ii
- radiation therapy
- diabetic rats
- double blind
- locally advanced
- radiation induced
- placebo controlled
- middle aged
- randomized controlled trial
- squamous cell carcinoma
- rectal cancer
- study protocol
- endothelial cells
- adverse drug
- oxide nanoparticles