The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen.

Laura L SwystunKenichi OgiwaraJesse D LaiJuha R M OjalaOrla RawleyFanny LassalleColleen NotleyOlle RengbyAlison MichelsKate NesbittKarl TryggvasonDavid Lillicrap

Published in: Journal of thrombosis and haemostasis : JTH (2019)

SCARA5 is an adhesive and endocytic receptor for VWF. In human tissues, SCARA5 is expressed by kidney podocytes and splenic littoral endothelial cells. SCARA5 may have a modest influence on VWF clearance in humans.

Keyphrases

endothelial cells
high glucose
induced apoptosis
induced pluripotent stem cells
pluripotent stem cells
binding protein
cell cycle arrest
cell death
cell proliferation