Serinol-Based Versatile Disulfide-Reducing Reagent.

Babita KushwahaSinenhlanhla N Mthembu Anamika Sharma Fernando Albericio Beatriz G de la Torre

Published in: Molecules (Basel, Switzerland) (2023)

Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a reducing agent was evaluated in both liquid and solid phases. The reducing capacity of this agent was comparable to that of DTT.

Keyphrases

randomized controlled trial