MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients.
Siri Fløgstad SvenssonSkarphedinn HalldorssonAnna LatyshevaElies Fuster-GarciaTrine HjørnevikJorunn Fraser-GreenRobin Anthony Birkeland BuggeJack GrinbandSverre HolmRalph SinkusEinar Osland Vik-MoKyrre Eeg EmblemPublished in: Neuro-oncology advances (2023)
MRE imaging of glioblastoma can provide noninvasive information on intratumoral heterogeneity. Regions of increased stiffness were associated with extracellular matrix reorganization. An expression signal associated with "stiff" biopsies correlated with shorter survival of glioblastoma patients.
Keyphrases
- extracellular matrix
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- poor prognosis
- magnetic resonance imaging
- prognostic factors
- healthcare
- high resolution
- computed tomography
- single cell
- genome wide
- mass spectrometry
- long non coding rna
- dna methylation
- patient reported outcomes
- ultrasound guided
- contrast enhanced