RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage.

Rodrigo Coutinho de AlmeidaYolande F M RamosAhmed MahfouzWouter den HollanderNico LakenbergEvelyn HoutmanMarcella van HoolwerffEka H E D SuchimanAlejandro Rodríguez RuizP Eline SlagboomHailiang MeiSzymon M KiełbasaRob G H H NelissenMarcel ReindersIngrid Meulenbelt

Published in: Annals of the rheumatic diseases (2018)

By an integrated approach of miRNA and mRNA sequencing data of OA cartilage, an OA miRNA interactome and related pathways were elucidated. Our functional data demonstrated interacting levels at which miRNA affects expression of genes in the cartilage and exemplified the complexity of functionally validating a network of genes that may be targeted by multiple miRNAs.

Keyphrases

electronic health record
big data
knee osteoarthritis
single cell
genome wide
poor prognosis
binding protein
machine learning
gene expression
dna methylation
genome wide identification
bioinformatics analysis
cancer therapy
data analysis
transcription factor
drug delivery
network analysis