Identification of a Novel SLC8A1-ALK Fusion and Non-Canonical Expression Significantly Responding to ALK-TKIs in Lung Adenocarcinoma: A Case Report.
Xingyu ZhuYuqi HeYin WangYan LeiXiaoxing SuYifan LiuShuangxiu WuZhengfu HePublished in: OncoTargets and therapy (2021)
A strategy combining DNA-targeted next-generation sequencing with RNA reverse transcriptase-polymerase chain reaction and sequencing, besides fluorescence in situ hybridization and immunohistochemistry, may provide an effective and practical solution for correct identification of partner genes and fusion structures in the diagnosis of ALK rearrangements, particularly for non-canonical expression patterns of ALK fusion events. The combined approach may lead to more benefits for patients.
Keyphrases
- advanced non small cell lung cancer
- poor prognosis
- bioinformatics analysis
- end stage renal disease
- single molecule
- circulating tumor
- newly diagnosed
- chronic kidney disease
- ejection fraction
- binding protein
- prognostic factors
- peritoneal dialysis
- single cell
- nucleic acid
- genome wide
- patient reported outcomes
- cancer therapy
- cell free
- solid state
- quantum dots
- genome wide analysis