Importance of genetic testing in unexplained cardiac arrest.
Steffany GrondinBrianna DaviesJulia Cadrin-TourignyChristian SteinbergChristopher C CheungPaloma JordaJeffrey S HealeyMartin S GreenShubhayan SanataniWael AlqarawiPaul AngaranLaura ArbourPavel AntiperovitchHabib KhanRichard LeatherPeter G GuerraLena RivardChristopher S SimpsonMartin GardnerCiorsti MacIntyreColette SeiferAnne FournierJacqueline JozaMichael H GollobGuillaume LettreMario TalajicZachary W M LaksmanJason D RobertsAndrew D KrahnRafik TadrosPublished in: European heart journal (2022)
Genetic testing identifies a disease-causing variant in 10% of apparent UCA survivors. The majority of disease-causing variants was located in cardiomyopathy-associated genes, highlighting the arrhythmogenic potential of such variants in the absence of an overt cardiomyopathy diagnosis. The present study supports the use of genetic testing including assessment of arrhythmia and cardiomyopathy genes in survivors of UCA.