Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague-Dawley rats.
Keshab Kumar KarnaBo Ram ChoiJae Hyung YouYu Seob ShinKiran Kumar SoniWan Shou CuiSung Won LeeChul Young KimHye Kyung KimJong Kwan ParkPublished in: Cancer cell international (2019)
ADR treatment can markedly impair testicular function and induce testicular cell death presumably by causing significant changes in oxidative stress, ER stress, and mitochondrial pathway. DA-9401 exerts beneficial effects against oxidative stress, ER stress, and mitochondria-mediated cell death pathway in testis tissue by up-regulating expression levels of tight junction protein markers, steroidogenic acute regulatory protein, GSK-3 alpha, and cation channels of sperm.
Keyphrases
- oxidative stress
- induced apoptosis
- cell death
- diabetic rats
- germ cell
- ischemia reperfusion injury
- dna damage
- endoplasmic reticulum stress
- signaling pathway
- binding protein
- cell cycle arrest
- poor prognosis
- protein protein
- drug induced
- transcription factor
- emergency department
- pi k akt
- high glucose
- respiratory failure
- amino acid
- intensive care unit
- ionic liquid
- aortic dissection
- extracorporeal membrane oxygenation