A Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies.

Martin Kulke Felix Nagel Lukas Schulig Norman GeistMarcel GaborJulia MayerleMarkus M LerchAndreas Link Mihaela Delcea

Published in: Journal of inflammation research (2021)

Based on our result, a hypothesis is formulated that explains the development of chronic pancreatitis through accelerated digestion of the mutant by trypsin.

Keyphrases

molecular dynamics
molecular dynamics simulations
single molecule
case control
protein kinase
wild type