Development of in vitro osteoporosis model in minipig proximal humerus and femur: validation in histological and biomechanical study.

We demonstrated that decalcification with EDTA solution significantly decreased aBMD, vBMD, and cortical thickness. Decalcified minipig bone using EDTA resulted in similar biomechanical properties as osteoporotic human bone with respect to anchor pull-out.