Sleep Apnea and Heart Failure-Current State-of-The-Art.
Tushar MenonDinesh K KalraPublished in: International journal of molecular sciences (2024)
Sleep-disordered breathing (SDB), including obstructive and central sleep apnea, significantly exacerbates heart failure (HF) through adverse cardiovascular mechanisms. This review aims to synthesize existing literature to clarify the relationship between SDB and HF, focusing on the pathophysiological mechanisms, diagnostic challenges, and the effectiveness of treatment modalities like continuous positive airway pressure (CPAP) and adaptive servo-ventilation ASV. We analyzed peer-reviewed articles from 2003 to 2024 sourced from PubMed, EMBASE, Scopus, and Web of Science databases. The prevalence of SDB in HF patients is high, often underdiagnosed, and underappreciated. Management strategies, including CPAP and ASV, have been shown to mitigate symptoms and improve cardiac function. However, despite the availability of effective treatments, significant challenges in screening and diagnosis persist, affecting patient management and outcomes. DB significantly impacts HF prognosis. Enhanced screening strategies and broader utilization of therapeutic interventions like CPAP and ASV are essential to improve the management and outcomes of HF patients with concomitant SDB. Future research should focus on refining diagnostic and treatment protocols to optimize care for HF patients with SDB.
Keyphrases
- sleep apnea
- positive airway pressure
- obstructive sleep apnea
- acute heart failure
- heart failure
- systematic review
- end stage renal disease
- palliative care
- randomized controlled trial
- healthcare
- risk factors
- ejection fraction
- chronic kidney disease
- left ventricular
- public health
- physical activity
- emergency department
- depressive symptoms
- type diabetes
- quality improvement
- pain management
- adipose tissue
- patient reported outcomes
- respiratory failure
- atrial fibrillation
- acute respiratory distress syndrome
- mechanical ventilation
- weight loss
- electronic health record