Biochemical and immunohistochemical analysis of tissue inhibitor of metalloproteinases-1 in human sound dentin.

Considering the role of TIMP-1, MMP-2, and MMP-9 within the connective tissues, clinically applicable protocols could be developed in the future to increase or decrease the level of TIMPs in human dentin to regulate the activity of MMPs, contributing to reduce caries progression and collagen degradation.