Secondary plasma cell leukaemia (PCL) with plasmablastic morphology.
Ke XuElisabeth NachevaPublished in: Journal of hematopathology (2024)
A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach.
Keyphrases
- bone marrow
- poor prognosis
- newly diagnosed
- multiple myeloma
- induced apoptosis
- flow cytometry
- peripheral blood
- cell cycle arrest
- single cell
- mesenchymal stem cells
- long non coding rna
- end stage renal disease
- cell therapy
- ejection fraction
- multiple sclerosis
- acute lymphoblastic leukemia
- chronic kidney disease
- acute myeloid leukemia
- endoplasmic reticulum stress
- oxidative stress
- patient reported outcomes
- cell death
- dna methylation
- gene expression
- single molecule
- acute respiratory distress syndrome
- ionic liquid
- extracorporeal membrane oxygenation