Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders.

P AuvinenJ VehviläinenH MarjonenV ModhukurJ SokkaE WallénK RämöL AholaA SalumetsT OtonkoskiH SkottmanM OllikainenR TrokovicH KahilaNina Kaminen-Ahola

Published in: BMC medicine (2022)

Our study shows the effects of early alcohol exposure on human embryonic and extraembryonic cells, introduces candidate genes for alcohol-induced developmental disorders, and reveals potential biomarkers for prenatal alcohol exposure.

Keyphrases

alcohol consumption
high glucose
diabetic rats
induced apoptosis
genome wide
gene expression
pregnant women
oxidative stress
drug induced
dna damage
signaling pathway
dna methylation
induced pluripotent stem cells
cell proliferation
endoplasmic reticulum stress
pluripotent stem cells